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To assess the potential of this study to inform treatment choices, we estimated the mean annual cost of treatment when the patient was using metformin. predicted mean annual cost for treatment when the patient was using metformin $3,067 (95% CI, $1,539- ₹7,924) and $18,917 (95% CI, $11,750- ₹26,000) when the patient was using levothyroxine; these are based on the mean estimated cost of treatment for the 1-year period 2005-2011 each of the four trials described in our article. Although the mean estimated cost for levothyroxine use with metformin varies depending on the trial (14, 17), estimated mean annual price that the patient would owe if using a single daily dose of metformin as opposed to a combination of multiple daily doses metformin and levothyroxine would be between $2,876 ($1,539-$18,917) and $19,000 ($11,750-$26,000).
Patients who chose to receive metformin |